منابع مشابه
Metabolism of the Nitrofurans I. Ultraviolet Absorption Studies of Urinary End-products after Oral Administration
The general antibacterial action in vitro of a variety of furan derivatives substituted in the 5 position with a nitro group has been reported by Dodd and Stilhnan (1, 2). That the presence of the nitro group is essential was established by comparison of the activities with those of the corresponding non-nitrated derivatives. All the nitrofurans except those limited by insolubility exhibited a ...
متن کاملMetabolism of the nitrofurans; ultraviolet absorption studies on urinary end-products after oral administration.
The general antibacterial action in vitro of a variety of furan derivatives substituted in the 5 position with a nitro group has been reported by Dodd and Stilhnan (1, 2). That the presence of the nitro group is essential was established by comparison of the activities with those of the corresponding non-nitrated derivatives. All the nitrofurans except those limited by insolubility exhibited a ...
متن کاملMetabolism of the nitrofurans. II. Incubation of Furacin with mammalian tissues.
Furacin* (5-nitro-2-furaldehyde semicarbazone) is an antibacterial agent effective against both Gram-negative and Gram-positive organisms (l-3). It has also been studied extensively, along with other nitrofurans, to determine its fate during metabolism in the body (4, 5). Certain of these nitrofurans having chemotherapeutic activity partially withstand metabolic breakdown in the body and are ex...
متن کاملMetabolism of the nitrofurans. III. Studies with xanthine oxidase in vitro.
For a better understanding of the mechanism of action of the nitrofurans in the mammalian organism, studies of their metabolism have been initiated. Excretion studies (1) have revealed that only a small part of most ingested nitrofurans appears unchanged in the urine. Bender and Paul (2) in preliminary studies have shown that 5-nitro-2-furaldehyde semicarbazone (Furacin’) undergoes degradation ...
متن کاملNitrofurans as radiosensitizers of hypoxic mammalian cells.
Our studies showed that various nitrofuran derivatives have excellent radiosensitizing properties in hypoxic Chinese hamster cells at concentrations at which there is no effect on plating efficiency. The radiosensitizing effect is primarily a dose-modifying effect, with nitrofurantoin, nitrofurazone, and nifuroxime (each at 500 ¿M) in complete medium giving enhancement ratios of 1.65, 2.0, and...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1949
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56751-x